Water Extract Influence of Stachytarpheta jamaicensis (L.) Vahl Leaves to Prevent Psoriasis Severity in Animal Model

Psoriasis is an autoimmune disease that characterized by the appearance of lesions on skin. The current treatment aims to control symptoms. efficacy Stachytarpheta jamaicensis (L.) Vahl’s for rheumatoid arthritis and systemic lupus erythematosus has been tested in animal models. aim this research was evaluate effect water extract S. leaves psoriasis model (male Balb/c mice) induced topically imiquimod. made boiling. divided into groups: normal, control, methotrexate 0.2 mg/kgBW, (doses 25, 50 100 mg/kgBW). measured parameters were Area Severity Index (PASI) score skin histopathology. results showed all doses could reduce PASI when compared group. Histological there a decrease keratin growth test animals given extract. Extracts at 25 mg/kgBW can thickening epidermis back ears. It be concluded leaf most effective activity prevent recurrence dose range mg/kgBW.Keywords: Psoriasis, extract, PASI, keratin, imiquimod